Staphylococcus lugdunensis IsdG Liberates Iron from Host Heme
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چکیده
منابع مشابه
Staphylococcus lugdunensis IsdG liberates iron from host heme.
Staphylococcus lugdunensis is often found as part of the normal flora of human skin but has the potential to cause serious infections even in healthy individuals. It remains unclear what factors enable S. lugdunensis to transition from a skin commensal to an invasive pathogen. Analysis of the complete genome reveals a putative iron-regulated surface determinant (Isd) system encoded within S. lu...
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33 Staphylococcus lugdunensis is a coagulase-negative Staphylococcus that is a commensal of 34 humans and an opportunistic pathogen. It can cause a spectrum of infections including those that are 35 associated with the ability to form biofilm such as endocarditis or indwelling medical devices. The 36 genome sequences of two strains revealed the presence of orthologues of the ica genes that are ...
متن کاملIron-regulated surface determinant (Isd) proteins of Staphylococcus lugdunensis.
Staphylococcus lugdunensis is the only coagulase-negative Staphylococcus species with a locus encoding iron-regulated surface determinant (Isd) proteins. In Staphylococcus aureus, the Isd proteins capture heme from hemoglobin and transfer it across the wall to a membrane-bound transporter, which delivers it into the cytoplasm, where heme oxygenases release iron. The Isd proteins of S. lugdunens...
متن کاملTight binding of heme to Staphylococcus aureus IsdG and IsdI precludes design of a competitive inhibitor.
The micromolar equilibrium constants for heme dissociation from IsdG and IsdI reported in the literature call into question whether these enzymes are actually members of the iron-regulated surface determinant system of Staphylococcus aureus, which harvests heme iron from a host during infection. In order to address this question, the heme dissociation constants for IsdG and IsdI were reevaluate...
متن کاملRuffling of metalloporphyrins bound to IsdG and IsdI, two heme-degrading enzymes in Staphylococcus aureus.
IsdG and IsdI are paralogous proteins that are intracellular components of a complex heme uptake system in Staphylococcus aureus. IsdG and IsdI were shown previously to reductively degrade hemin. Crystal structures of the apoproteins show that these proteins belong to a newly identified heme degradation family distinct from canonical eukaryotic and prokaryotic heme oxygenases. Here we report th...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2011
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.00436-11